Assay Specifics
3T3 Neutral Red Phototoxicity(3T3 NRU PT)

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Assay Specifics

Test Model: 3T3 cells seeded in duplicate 96-well plates(light/dark)

3T3 Fibroblast Cells

Endpoints:

  • IC50 (Concentration of test material that causes a 50% decrease in viability, relative to Controls)
  • PIF (Photo-Irritation-Factor) - comparison of the IC50 of treated cells in the presence of UVA/Solar Simulated light exposure to the IC50 of treated cells in the absence of UVA exposure.
  • MPE (Mean Photo Effect) - comparison of the response curve of treated cells in the presence of UVA/Solar Simulated light exposure to the response curve of treated cells in the dark unirradiated group.

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MB specializes in the conduct of Good Laboratory Practice (GLP) compliant phototoxicology assays. MB Research studies are designed to meet the requirements of the applicable regulatory agencies, or tailored to meet your specific needs. MB Research offers more than 40 years experience in the conduct of acute, sub-chronic and chronic toxicology designed to meet regulatory guidelines. Contact MB for More Info